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Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism

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23.3 ± 14.4, p = 0.01) years, and of the DIALONG participants before or during puberty (12.3 ± 6.0 vs